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Cbl and Human Myeloid Neoplasms: The Cbl Oncogene Comes of Age | Cancer Research
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The Heatmap of CBL mutations. (A) PamGene analysis was performed to detect the RTK phosphorylation difference between CBL WT and mutants.
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CARM1-dependent methylation of ELAVL1/HuR on Arginine 217. (A) Western
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(a) 293T cells were transiently transfected with either the EGFR alone, HA tagged cbl-b and the EGFR, or with HA tagged c-cbl and the EGFR.
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CBL-B interacts with BCR/ABL but not PI3K or CRKL in transformed cells. Lysates of 30×106 Ba/F3 or Ba/F3.p210 cells were used to immunoprecipitate (a) CBL ...
Identification of acquired isodisomy of 11q in JMML and CBL mutations. CNAG output for JMML UPN 1, UPN 18 and UPN 38. Left: Total copy numbers (tCNs) (red ...
Effect of nitrosylcobalamin (NO-Cbl) on the induction of apoptosis-related mRNA
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Detection of Human CBL by Western Blot.
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Oscar, who scientists dubbed the "miracle dog," survived an aggressive form of cancer thanks a drug known as NO-Cbl. The drug may lead to a powerful new ...
a, Copy number profiles of 17 cases with myeloid neoplasms showing 11qUPD. Regions of copy number (CN) gains, losses and aUPD are depicted in different ...
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Domain structure of Cbl proteins. The sequence of human c-Cbl is aligned with that of chicken c-Cbl (Wang et al., 2000b), Xenopus c-Cbl (Adler et al., ...
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(a) c-Cbl and Cbl-b expression in normal mature T cells and thymocytes was analyzed by immunoblotting. For protein loading controls, the same membrane was ...
Comparison of standard deviation terms for basin and nonbasin models.
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CBL attenuates Smad3 nuclear translocation. After Myc-CBL was transfected in Hs578T cell line with or without 5 ng/ml TGF-β1 treatment for 1 h, ...
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Time course and dose response of insulin-induced Cbl tyrosine phosphorylation and association with CAP
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(a) Flow cytometry of CD3ε expression on Jurkat T cell lines (right margin) transiently transfected with GFP or SLAP-GFP with or without c-Cbl expression ...
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p95Cbl is generated by a 111 aa deletion encompassing the RING finger domain. (a) Local amino acid alignment of c-Cbl, 70Z Cbl and p95Cbl depicting the ...
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C-CBL knockdown promotes cell migration. a H1299 and U251MG cells were transfected with si-Control or si-C-CBL, and subjected to wound healing assay in ...
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UBASH3B/Sts-1 promotes the growth of AML1-ETO cells through the interaction with CBL. (a) Two shRNAs showed efficient UBASH3B/Sts-1 knockdown and ...
(a) c-Cbl siRNA was transfected into FAK−/− cells expressing siRNA resistant, HA-tagged wild-type c-Cbl or c-Cbl mutants with defective E3 ligase activity ...
(a) BaF3-GMR-HA-Cbl(WT or Y371H) cells were plated in the presence or absence of increasing concentrations of 6-mercaptopurine ...
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Figure 1
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(b) Interaction of endogenous Cbl and βPix was detected in cell lysates from breast ...
Scheme 1. Numbering scheme for NOCbl. The three orientations of the oxygen atom of
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Cbl-b, but not c-Cbl, associates with ubiquitinated proteins. (a) 293T cells were transfected with HA epitope tagged ubiquitin and Cbl-b.
Cbl inactivation does not reverse TCR signaling defects in Lck−/− DP thymocytes.
(a) COS-7 cells were transfected with CSF-MET and SOCS1, c-Cbl or both. Control empty vectors were used to equalize total DNA used for transfection.
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Cells were cultured for five (a–d, g, h) or eight days (e, f) in the presence of delipidated serum plus (a) no addition, (b) NGF, 100 ng per ml, .
Oscar the Bichon Frise who was the first patient to be treated with NO-Cbl for an aggressive cancer in 2004. The drug was an astounding success.
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Figure 4
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Results from sera of individual 9-month-old cbl-b+/+ and cbl-b-/- littermate mice are shown.b, Syngeneic MLRs using lymph-node ...
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cbl-3 interacts with SH3 proteins. Cell lysates containing cbl-3L (top panel) or cbl-b (bottom panel) were precipitated with 5 μg of GST fusion proteins of ...
EXAMPLE 10: When there is no CBL-VDL made under pressure, the un-pressured version can be used to interpret micro-annulus. High amplitude early arrivals ...
K10.6 administration induces the phosphorylation of Cbl-b but not SHP-1
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